科学网博友罗广营老师提出的研究课题“父母糖尿病是否后代有患眼疾病的风险？”的信息检索分析要求，我在PUBMED数据库中检索到相关文献11篇，从研究文献报道看到父母糖尿病后代患眼疾病的风险是存在的。

其中有3篇论文研究了父母糖尿病与后代弥漫性毒性甲状腺肿(Graves' disease、Template:Flajani-Basedow-Graves disease)的关系，因产生针对TSH受体的自身抗体而导致弥漫性甲状腺肿大、甲状腺毒症以及相关眼征、皮肤损害等的一种自身免疫性疾病。由于弥漫性甲状腺肿大和甲状腺毒症共存，故名“弥漫性毒性甲状腺肿”。

父母糖尿病后代患眼疾病是否有遗传基因？知识发现结果见下。

罗广营  2015-5-18 13:26 

恩 谢谢 许老师，我还想问问父亲患糖尿病或母亲患糖尿病是否是后代患眼睛疾病的风险因子？也就是说，如果家庭中父母有患糖尿病，是不是后代得眼睛疾病的风险高，比如白内障、青光眼、视网膜血管病变、AMD等等。之所以这么问，是因为我发现母亲患糖尿病与后代的精神疾病相关。而眼睛是脑的延伸，所以考虑是不是父母源糖尿病有可能潜在地促进后代眼睛疾病的发生？不知道有没有意义。

罗广营  2015-5-18 10:42 

许老师，您好！想请您帮我动用你们的信息分析处理一下：父母源糖尿病和后代眼睛疾病之间的关系。想探讨一个问题如果家族有糖尿病，后代患眼睛疾病的风险较高？也就是说，父母源糖尿病是否是后代眼睛发育障碍和眼睛疾病的风险因子？谢谢！如果方便，麻烦您给予帮助。

 博主回复(2015-5-18 13:10)：

父母亲都是糖尿病患者，其子女约有5％会患糖尿病，若父母亲中只有一方有糖尿病，则子女得病的机会更少。

博主回复(2015-5-18 11:53)：罗老师，我做些信息分析和知识发现，看看关联如何。

父母糖尿病后代眼疾病 Parents diabetes offspring eye disease

检索分析系统 http://www.pubmedplus.cn/

PUBMED医学文献数据库检索到有关父母糖尿病后代眼疾病研究论文11篇分布如下：

检索结果11篇论文如下：

知识发现结果如下：

A-query: Parents diabetes
C-query: offspring eye disease

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 11 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 8839 and can be accessed from the start page after you leave this session. There are 144 terms on the current B-list (39 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

job id # 8839 started Mon May 18 01:43:44 2015
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: Parents diabetes Mon May 18 01:43:53 2015

A query = Parents diabetes started Mon May 18 01:43:53 2015
A query resulted in 3968 titles
C_query_raw: offspring eye disease Mon May 18 01:44:07 2015

C: offspring eye disease 638

A: Parents diabetes 3968

AC: ( Parents diabetes ) AND ( offspring eye disease ) 11

C_query_raw: offspring eye disease Mon May 18 01:44:26 2015

C: offspring eye disease 638

A: Parents diabetes 3968

AC: ( Parents diabetes ) AND ( offspring eye disease ) 11

C query = offspring eye disease started Mon May 18 01:44:26 2015
C query resulted in 638 titles
A AND C query resulted in 11 titles
1520 B-terms ready on Mon May 18 01:44:34 2015

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
144 B-terms left after filter executed Mon May 18 01:52:02 2015

B-list on Mon May 18 01:55:23 2015
1 ctla-4
2 genome wide
3 pax6
4 myopia
5 drb1
6 candidate gene
7 quantitative trait loci
8 receptor gene
9 bardet biedl syndrome
10 hla
11 4p
12 major gene
13 retinitis pigmentosa
14 gene associated
15 allele
16 diabetes mellitus
17 leber congenital amaurosis
18 inflammatory bowel disease
19 allele specific
20 diabetes
21 hydrocephalus
22 optic atrophy
23 obesity
24 chemokine
25 twin
26 trait
27 locus
28 insulin
29 turner syndrome
30 gene a
31 uk
32 mitochondrial
33 gene chromosome
34 cytokine
35 tumor suppressor
36 hydroxysteroid dehydrogenase
37 weight
38 syndrome gene
39 gene

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=8839