背景回顾-TCP：Although TCP proteins bind primarily to promoter regions, some also target gene bodies for expression activation.

提出问题：However, the underlying regulatory mechanism remains unknown.

主要研究：Here we show that TEN, a TCP from cucumber (Cucumis sativus L.), controls the identity and mobility of tendrils.

结果1-TEN如何发挥作用：Through its C terminus, TEN binds at intragenic enhancers of target genes; its N-terminal domain functions as a non-canonical histone acetyltransferase (HAT) to preferentially act on lysine 56 and 122 of the histone H3 globular domain. 

结果2-HAT功能：This HAT activity is responsible for chromatin loosening and host-gene activation.

结果3-HAT保守性：The N termini of all tested CYCLOIDEA and TEOSINTE BRANCHED 1-like TCP proteins contain an intrinsically disordered region; despite their sequence divergence, they have conserved HAT activity.

结论：This study identifies a non-canonical class of HATs and provides a mechanism by which modification at the H3 globular domain is integrated with the transcription process.