Francis Crick, together with James Watson, discovered the double-helix
structure of the DNA molecular in 1953 and received the Nobel Prize for
Medicine or Physiology in 1962.
Crick published an autobiography titled "What Mad Pursuit: A Personal
View of Scientific Discovery" in 1988. On pp. 157 ~ 158 of that book, there is
this paragraph: "Curiously enough, in biology it is sometimes those
basic problems that look impossibly difficult to solve which yield the
most easily. This is because there may be so few even remotely possible
solutions that eventually one is led inexorably to the correct answer.
The biological problems that are really difficult to unscramble are
those where there is almost an infinity of plausible answers and one has
painstakingly to attempt to distinguish between them."
Obviously, the lesson that Crick was teaching in the above paragraph is
this: Do not be afraid of attempting to crack the most fundamental
problems in your research field!
I found that someone had uploaded "What Mad Pursuit" on sina.com's file
sharing site. If you are interested in reading the book, please go to
the following link to download the book: http://ishare.iask.sina.com.cn/f/6458646.html
(The file is in .DJVU format. If you don't have a DJVU reader on your
computer, do a Google search and then download and install one for
yourself.)