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震撼---将五十年诺奖浓缩到八分钟的动画
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Recently I saw an animation named “The inner life of the cell”, which was
made by Howard Hughes Medical Institute and Harvard University
Biovision. It can be watched online only:
http://aimediaserver.com/studiodaily/harvard/harvard.swf
Watching this animation was so overwhelming that it is almost a religious
experience for me as a biophysics researcher. What you try to
understand in your day-to-day research is presented to you face to
face with such a miraculous vivacity. Every detail is painfully accurate
in each process. I believe that everybody, who is doing research in
molecule biology and molecule modeling, would be totally overwhelmed by this video.
Even an outsider would be impressed with its fabulous 3D effect, it is
better to know what is really going on in each process.
At first, the white blood cell rolls along the inner wall of the blood
capillary. After the first zoom-in, you can see the surface of the white
cell ( the bumpy stuffs ). With more zoom-in, the hair stuff, the
proteins on the surfaces of while blood cell, begin to attach
themselves on the membrane protein of the capillary cells.
Later, you will see the ruff sea, which is just the membrane of the cell.
The floating dish is the proteins to get the message from
the receptors and spread it through the white cell. Then some molecule
messengers promote the polymerization of Actin filaments ( the railway
inside the cell for transportation) while other proteins to cut the
filaments in the other end; some other messengers cause the small tube
structures to polymerize forward on one end and break down at
the other end. What happened flatten out the cell and makes it further
adhere to the capillary cells, which we can see later.
It is almost surreal to watch a molecule motor – Kinesin walking along
the tube while dragging a large bag hundreds times larger than itself.
At the same time, a signal is sent to the nucleus to produce
relevant mRNA, which are passing through pores in the nucleus membranes.
Then they immediately fold into the circle. The large ribosomes
attach themselves to the chain of mRNA, read the information on it and
produce the polymer chain of certain proteins.
These proteins are sorted and packaged by some macromolecules,
then are sent to the membrane of the white cell. You can see the Kinesins are
pulling them towards something like blue mushrooms (cell membranes).
These packages merged with cell membranes and release the soluble
proteins into intercellular space. These release proteins further stimulate
cells to produce more receptors to strength the contact between cells,
which lead the white cell to flatten out and squeeze itself through
the capillary membrane.
It is really a wonder to include the information and logic encoded in
4 billion years evolution and discovered by the hard-working research
in the past 50 years in this 8 minute video.
https://m.sciencenet.cn/blog-3468-8450.html
上一篇：生物物理的摩西十戒
下一篇：最好的物理老师
made by Howard Hughes Medical Institute and Harvard University
Biovision. It can be watched online only:
http://aimediaserver.com/studiodaily/harvard/harvard.swf
Watching this animation was so overwhelming that it is almost a religious
experience for me as a biophysics researcher. What you try to
understand in your day-to-day research is presented to you face to
face with such a miraculous vivacity. Every detail is painfully accurate
in each process. I believe that everybody, who is doing research in
molecule biology and molecule modeling, would be totally overwhelmed by this video.
Even an outsider would be impressed with its fabulous 3D effect, it is
better to know what is really going on in each process.
At first, the white blood cell rolls along the inner wall of the blood
capillary. After the first zoom-in, you can see the surface of the white
cell ( the bumpy stuffs ). With more zoom-in, the hair stuff, the
proteins on the surfaces of while blood cell, begin to attach
themselves on the membrane protein of the capillary cells.
Later, you will see the ruff sea, which is just the membrane of the cell.
The floating dish is the proteins to get the message from
the receptors and spread it through the white cell. Then some molecule
messengers promote the polymerization of Actin filaments ( the railway
inside the cell for transportation) while other proteins to cut the
filaments in the other end; some other messengers cause the small tube
structures to polymerize forward on one end and break down at
the other end. What happened flatten out the cell and makes it further
adhere to the capillary cells, which we can see later.
It is almost surreal to watch a molecule motor – Kinesin walking along
the tube while dragging a large bag hundreds times larger than itself.
At the same time, a signal is sent to the nucleus to produce
relevant mRNA, which are passing through pores in the nucleus membranes.
Then they immediately fold into the circle. The large ribosomes
attach themselves to the chain of mRNA, read the information on it and
produce the polymer chain of certain proteins.
These proteins are sorted and packaged by some macromolecules,
then are sent to the membrane of the white cell. You can see the Kinesins are
pulling them towards something like blue mushrooms (cell membranes).
These packages merged with cell membranes and release the soluble
proteins into intercellular space. These release proteins further stimulate
cells to produce more receptors to strength the contact between cells,
which lead the white cell to flatten out and squeeze itself through
the capillary membrane.
It is really a wonder to include the information and logic encoded in
4 billion years evolution and discovered by the hard-working research
in the past 50 years in this 8 minute video.
https://m.sciencenet.cn/blog-3468-8450.html
上一篇：生物物理的摩西十戒
下一篇：最好的物理老师
