Thymidine

国际站：Thymidine

中文名：胸苷

CAS：50-89-5

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：胸苷是脱氧核糖核酸的特定前体，用作细胞同步化剂。胸苷是一种 DNA 合成 抑制剂，可在 DNA 复制之前将细胞停滞在 G1/S 边界^[1][2] [3]. IC50 和目标：DNA 合成^[2] 。

体内：胸苷（500 mg/kg；腹腔注射；每天两次）完全逆转甲氨蝶呤和 Tomudex 诱导的 CD4⁺Vβ8⁺ 和 CD8^{+< 缺失/sup>Vβ8+ T 细胞 [3]。}

参考文献：[1]. Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8(17).[2]. FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181(4604):274-5.FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181(4604):274-5.[3]. Izeradjene K, et al. Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independentdeletion of superantigen-reactive peripheral T cells. Int Immunol. 2001 Jan;13(1):85-93.