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封面解读

陆剑、乐敏

The entire image is composed of viral particles, symbolizing the continuous adaptation and evolution of the SARS-CoV-2 population, with scenes of human activity embedded. On the right, a researcher performs in silico simulations to recreate the ongoing evolution of viral populations. Colorful waveforms above signify epidemiological and evolutionary trends captured by the SIRSVIDE model, introduced by Jin et al. This innovative model simulates the transmission and evolutionary dynamics of viral populations, revealing under large susceptible host populations and high mutation rates, viral populations evolve towards higher transmissibility, enhanced immune evasion capabilities, and reduced pathogenicity. On the left, a worker disinfects a public area, representing another study by Huang et al. on the impact of COVID-19-related nonpharmaceutical interventions on diarrheal diseases and zoonotic Salmonella. This cover encapsulates understanding viral evolution requires a holistic perspective considering both the inherent properties of viruses and the myriad ways in which human factors shape the invisible battlefield of infectious diseases.

目     录

导     读

1.International cooperation in science, technology, and health, challenges and perspectives

通讯作者：André Costa Lobato, Carlos Medicis Morel, 沈逸

引用：

Lobato AC, Morel CM, Shen Y. International cooperation in science, technology, and health, challenges and perspectives. hLife 2024;2:207–210.

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2.Exploring structure-based drug discovery of GPCRs beyond the orthosteric binding site

通讯作者：黄牛

本文系统地总结了G蛋白偶联受体（G-protein coupled receptors, GPCRs）别构位点的结构信息和调控功能机制，并且梳理了目前已经发表的基于GPCRs结构的虚拟筛选（Structure-based virtual screening, SBVS）研究，深入探讨了靶向GPCRs别构位点进行药物虚拟筛选和设计所具有的广阔前景以及面临的挑战。

引用：

Chen Z, Ren X, Zhou Y, et al. Exploring structure-based drug discovery of GPCRs beyond the orthosteric binding site. hLife

2024;2:211–226.

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3.Modeling viral evolution: A novel SIRSVIDE framework with application to SARS-CoV-2 dynamics

通讯作者：陆剑

本研究研发了SIRSVIDE（ Susceptible-Infected-Recovered-Susceptible-Variation-Immune Decay-Immune Escape ）的新型计算模型，用于模拟病毒种群的传播和进化动态。

引用：

Jin K, Tang X, Qian Z, et al. Modeling viral evolution: A novel SIRSVIDE framework with application to SARS-CoV-2 dynamics. hLife 2024;2:227–245.

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4.Impact of COVID-19-related nonpharmaceutical interventions on diarrheal diseases and zoonotic Salmonella

通讯作者：乐敏

COVID-19相关的非药物干预措施（Nonpharmaceutical interventions，NPIs）降低了浙江省杭州市急性腹泻发病率，但非伤寒型沙门菌（Non-typhoidal Salmonella，NTS）的检出量意外上升，菌株基因型也产生了显著的变化；此外，NTS人畜共患传播的规模也减小，预示着NPIs对NTS的防控可能产生意外的积极影响。

引用：

Huang L, Zhou H, Chen J, et al. Impact of COVID-19-related nonpharmaceutical interventions on diarrheal diseases and zoonoticSalmonella. hLife 2024;2:246–256.

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5.Safety and immunogenicity of COVID-19 vaccine ZF2001 in Chinese aged 60 years and older

通讯作者：胡忠玉、钟再新、丁帆、李燕

本研究报道了基于原型株设计的新冠疫苗ZF2001 在中国老年人群中的安全性和免疫原性研究以及对奥密克戎变异株的有效性。

引用：

Gao L, Yang H, He P, et al. Safety and immunogenicity of COVID-19 vaccine ZF2001 in Chinese aged 60 years and older. hLife 2024;2:257–261.

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期刊简介

hLife是中国科学院微生物研究所主办，中国生物工程学会，浙江大学陈廷烨大健康学院，西湖大学医学院，上海市免疫治疗创新研究院和广州霍夫曼免疫研究所联合支持，与国际出版商爱思唯尔合作的的健康科学领域综合性英文期刊。

hLife聚焦健康科学领域的前沿进展，旨在促进基础研究与临床应用的融合发展。期刊发表与医学相关各研究领域最新成果，学科领域包括（但不限于）病原生物学、流行病学、生理学、免疫学、结构生物学、疾病监测、肿瘤、药物、疫苗和健康政策等。

2022年成功入选“中国科技期刊卓越行动计划高起点新刊”。

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