Controlling gene expression in response to stress,Nature Reviews Genetics 12, 833-845,

逆境反应的基因表达调控

Acute stress puts cells at risk, and rapid adaptation is crucial for maximizing cell survival. Cellular adaptation mechanisms include modification of certain aspects of cell physiology, such as the induction of efficient changes in the gene expression programmes by intracellular signalling networks. Recent studies using genome-wide approaches as well as single-cell transcription measurements, in combination with classical genetics, have shown that rapid and specific activation of gene expression can be accomplished by several different strategies. This article discusses how organisms can achieve generic and specific responses to different stresses by regulating gene expression at multiple stages of mRNA biogenesis from chromatin structure to transcription, mRNA stability and translation.

全文网址:http://www.nature.com/nrg/journal/v12/n12/abs/nrg3055.html?lang=en?WT.ec_id=NRG-201112.

可惜现在我自己都没全文,按我的习惯如果有的话,我会共享的.这篇文章会对逆境中,mRNA产生的多个环节的表达调控进行总结,从染色质结构到转录,mRNA的稳定性和翻译.