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速看，潍坊国际风筝节也见不到的“风筝”

已有 1684 次阅读 2022-12-27 15:29 |个人分类:封面故事|系统分类:图片百科

（图1）
图片来源于网络

近日，莫斯科第18届风筝节“彩色天空”于周末在察里津诺森林保护区举办。各式各样地风筝牢牢抓住了人们的视线，说道风筝节，就不得不提起潍坊国际风筝节。

谁还能不知道潍坊国际风筝节呢？

每年的潍坊国际风筝节，你都能在潍坊天空看到各式各样的风筝，只有你想不到的，没有她们做不出来的。因疫情，今年四月的潍坊国际风筝节延期举办。

往期潍坊国际风筝节的风筝，图片来源于网络（图2-4）

嘿，这大风筝可真行哎，就这，还能有在这看不到的风筝？快拿出来看看。
我这个啊，不一般，没点‘真材实料’还真看不透。不信你往这瞧

“几个细胞球随DNA而制的特制风筝线随风舞动，细胞球或加或减，随需要而定。”

文章连接：https://www.scimage.cn/artwork/2473.html?continueFlag=1237a9941f8ca8486ad5a2d289b2ab3b

摘要：
Recent transcriptome analysis indicates that > 90% of human genes undergo alternative splicing, underscoring the contribution of differential RNA processing to diverse proteomes in higher eukaryotic cells. The polypyrimidine tract-binding protein PTB is a well-characterized splicing repressor, but PTB knockdown causes both exon inclusion and skipping. Genome-wide mapping of PTB-RNA interactions and construction of a functional RNA map now reveal that dominant PTB binding near a competing constitutive splice site generally induces exon inclusion, whereas prevalent binding close to an alternative site often causes exon skipping. This positional effect was further demonstrated by disrupting or creating a PTB-binding site on minigene constructs and testing their responses to PTB knockdown or overexpression. These findings suggest a mechanism for PTB to modulate splice site competition to produce opposite functional consequences, which may be generally applicable to RNA-binding splicing factors to positively or negatively regulate alternative splicing in mammalian cells.

YuanchaoXue, YuZhou, TongbinWu, TuoZhu, XiongJi, Young-SooKwon, ChaoZhang, GeneYeo, Douglas L.Black, HuiSun, Xiang-DongFu, YiZhang团队于Molecular Cell发表的Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping

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