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2023年8月嘲风作品集（一）

已有 573 次阅读 2023-10-31 14:36 |个人分类:作品发表|系统分类:论文交流

▲ Vol 81 Issue 08 | August , 2023

生物大分子介质中的反常扩散动力学理论

魏文杰, 陈文龙, 戴晓彬, 燕立唐

生命体系中的扩散行为涉及营养摄取和药物递送等重要的生命过程. 深入了解粒子在生物大分子介质中的扩散行为将有助于理解相关生命现象以及发展新型医用材料. 生物大分子介质中的扩散行为往往是反常的, 不能简单地基于传统扩散常数方程进行描述. 这通常归因于生物介质中的拥挤环境与复杂相互作用使扩散产生了持续相关性, 进而导致中心极限定理不再适用. 从反常扩散的扩散系数、均方位移以及位移概率分布函数三个方面分析了反常扩散的机理与物理特征, 综述了近年来针对大分子介质中反常扩散的研究进展. 随后概述了反常扩散的物理模型与现有理论框架. 最后对生物大分子介质中反常扩散动力学理论的未来发展方向进行了展望.

http://sioc-journal.cn/Jwk_hxxb/CN/10.6023/A23040172

▲ Vol 62 Issue 31 | 01 August , 2023

Gold-Catalyzed Amine Cascade Addition to Diyne-Ene: Enantioselective Synthesis of 1,2-Dihydropyridines

Jingwen Wei, Dr. Yangyang Xing, Dr. Xiaohan Ye, Bao Nguyen, Dr. Lukasz Wojtas, Prof. Dr. Xin Hong, Prof. Dr. Xiaodong Shi

Axially enantioselective binuclear gold(I) catalysts fly as swallowtail butterflies around a mechanical hand providing a chiral environment. The gold microchip on the hand symbolizes the crucial role of gold catalysis in alkyne activation. Using the gold-catalyzed condensation of amine and diyne-ene, the first example of enantioselective 1,2-dihydropyridine synthesis through a formal [3+2+1] fashion is reported by Xin Hong, Xiaodong Shi et al. in their Research Article (e202305409).

https://onlinelibrary.wiley.com/doi/10.1002/anie.202308529

▲ Vol 57 Issue 30 | 01 August , 2023

Detection of Various Microplastics in Patients Undergoing Cardiac Surgery

Yunxiao Yang, Enzehua Xie, Zhiyong Du, Zhan Peng, Zhongyi Han, Linyi Li, Rui Zhao, Yanwen Qin, Mianqi Xue, Fengwang Li, Kun Hua, and Xiubin Yang

Microplastics have been detected in human stool, lungs, and placentas, which have direct exposure to the external environment through various body cavities, including the oral/anal cavity and uterine/vaginal cavity. Crucial data on microplastic exposure in completely enclosed human organs are still lacking. Herein, we used a laser direct infrared chemical imaging system and scanning electron microscopy to investigate whether microplastics exist in the human heart and its surrounding tissues. Microplastic specimens were collected from 15 cardiac surgery patients, including 6 pericardia, 6 epicardial adipose tissues, 11 pericardial adipose tissues, 3 myocardia, 5 left atrial appendages, and 7 pairs of pre- and postoperative venous blood samples. Microplastics were not universally present in all tissue samples, but nine types were found across five types of tissue with the largest measuring 469 μm in diameter. Nine types of microplastics were also detected in pre- and postoperative blood samples with a maximum diameter of 184 μm, and the type and diameter distribution of microplastics in the blood showed alterations following the surgical procedure. Moreover, the presence of poly(methyl methacrylate) in the left atrial appendage, epicardial adipose tissue, and pericardial adipose tissue cannot be attributed to accidental exposure during surgery, providing direct evidence of microplastics in patients undergoing cardiac surgery. Further research is needed to examine the impact of surgery on microplastic introduction and the potential effects of microplastics in internal organs on human health.

https://pubs.acs.org/doi/10.1021/acs.est.2c07179

▲ Vol 145 Issue 30 | 02 August , 2023

Cathode Kinetics Evaluation in Lean-Electrolyte Lithium–Sulfur Batteries

Zi-Xian Chen, Qian Cheng, Xi-Yao Li, Zheng Li, Yun-Wei Song, Furong Sun, Meng Zhao, Xue-Qiang Zhang, Bo-Quan Li, and Jia-Qi Huang

Lithium–sulfur (Li–S) batteries afford great promise on achieving practical high energy density beyond lithium-ion batteries. Lean-electrolyte conditions constitute the prerequisite for achieving high-energy-density Li–S batteries but inevitably deteriorates battery performances, especially the sulfur cathode kinetics. Herein, the polarizations of the sulfur cathode are systematically decoupled to identify the key kinetic limiting factor in lean-electrolyte Li–S batteries. Concretely, an electrochemical impedance spectroscopy combined galvanostatic intermittent titration technique method is developed to decouple the cathodic polarizations into activation, concentration, and ohmic parts. Therein, activation polarization during lithium sulfide nucleation emerges as the dominant polarization as the electrolyte-to-sulfur ratio (E/S ratio) decreases, and the sluggish interfacial charge transfer kinetics is identified as the main reason for degraded cell performances under lean-electrolyte conditions. Accordingly, a lithium bis(fluorosulfonyl)imide electrolyte is proposed to decrease activation polarization, and Li–S batteries adopting this electrolyte provide a discharge capacity of 985 mAh g–1 under a low E/S ratio of 4 μL mg–1 at 0.2 C. This work identifies the key kinetic limiting factor of lean-electrolyte Li–S batteries and provides guidance on designing rational promotion strategies to achieve advanced Li–S batteries.

https://pubs.acs.org/doi/10.1021/jacs.3c02786

▲ Vol 35 Issue 32 | 10 August , 2023

Circadian Clock Regulation via Biomaterials for Nucleus Pulposus

Wei Chen, Dandan Zheng, Hao Chen, Tingjun Ye, Zhihong Liu, Jin Qi, Hongxing Shen, Huitong Ruan, Wenguo Cui, Lianfu Deng

Tissue Regeneration
Inspired by the regulation of cellular circadian clock on tissue regeneration, in article number 2301037, Huitong Ruan, Wenguo Cui, Lianfu Deng, and co-workers report circadian-clock-regulating biomaterials that are fabricated using the air-microfluidic technique. The chemical cross-linking between poly(vinyl alcohol) and modified phenylboronic acid can effectively activate the intrinsic circadian clock of nucleus pulposus cells via the PI3K-AKT pathway, thus improving the regeneration of intervertebral discs.

https://onlinelibrary.wiley.com/doi/10.1002/adma.202370229

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