The latest issue of Drug Discovery Today is packed full of industry focused research articles, new developments in drug discovery, and expert comment and opinion. View Drug Discovery Today now »» Highlights include: Expression of microRNA in ischemic heart disease Fiber-based bottom-up tissue engineering Angiotension receptor blockers for Marfan’s syndrome Small molecule inhibitors of Ebola virus infection
You can access the issue at: http://e-ditionsbyfry.com/olive/ODE/DDT/Default.aspx?href=DDT/2015/02/01 Enjoy your digital edition! EDITORIAL 167 How many times should we screen a chemical library to discover an anticancer drug? Miguel López-Lázaro PERSPECTIVE FEATURE 170 Post-approval fate of pharmaceutical companies Michael S. Kinch 175 The Pistoia Alliance Controlled Substance Compliance Service Project: from start to fi nish Daniel Taylor, Stuart G. Bowden, Reinhard Knorr, Derek R. Wilson, John Proudfoot and Anne E. Dunlop 181 The Joint European Compound Library: boosting precompetitive research Jérémy Besnard, Philip S. Jones, Andrew L. Hopkins and Andrew D. Pannifer REVIEWS FOUNDATION 187 Computational systems biology approaches to anti-angiogenic cancer therapeutics Stacey D. Finley, Liang-Hui Chu and Aleksander S. Popel 198 Radionuclides in drug development Philipp Uhl, Gert Fricker, Uwe Haberkorn and Walter Mier KEYNOTE 209 Molecular perspectives on solid-state phase transformation and chemical reactivity of drugs: metoclopramide as an example Shan-Yang Lin 223 Differential expression of microRNAs in ischemic heart disease Minwoo A. Song, Alexandra N. Paradis, Maresha S. Gay, John Shin and Lubo Zhang GENE-TO-SCREEN 236 Cell-laden microfi bers for bottom-up tissue engineering Hiroaki Onoe and Shoji Takeuchi INFORMATICS 247 Databases and collaboration require standards for human stem cell research Nadia K. Litterman and Sean Ekins REVIEWS (continued) POST SCREEN 255 Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery Sandeepkumar Kothiwale, Corina M. Borza, Edward W. Lowe Jr., Ambra Pozzi and Jens Meiler 262 Angiotensin receptor blockers: a panacea for Marfan syndrome and related disorders? Bart L. Loeys 267 Farnesyltransferase and geranylgeranyltransferase I: structures, mechanism, inhibitors and molecular modeling Mingyun Shen, Peichen Pan, Youyong Li, Dan Li, Huidong Yu and Tingjun Hou 277 Small molecule inhibitors of ebola virus infection Edwige Picazo and Fabrizio Giordanetto 287 DIARY | 
