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脊髓损伤再生的基因知识发现

已有 3043 次阅读 2010-12-28 09:31 |个人分类:知识发现|系统分类:论文交流|关键词:学者| 基因, 知识发现, 脊髓损伤, 再生

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

Start A-Literature C-Literature B-list Filter Literature
  A-query: spinal cord injury
C-query: axonal regeneration
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 1103 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 29778 and can be accessed from the start page after you leave this session. There are 644 terms on the current B-list (274 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 29778 started Mon Dec 27 20:58:40 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
29778 Search ARROWSMITH A
A_query_raw: spinal cord injuryMon Dec 27 20:58:55 2010

A query = spinal cord injury started Mon Dec 27 20:58:55 2010
A query resulted in 42629 titles
29778 Search ARROWSMITH C
C_query_raw: axonal regeneration Mon Dec 27 20:59:12 2010

C: axonal regeneration 5500

A: pubmed_query_A 42629

AC: ( spinal cord injury ) AND ( axonal regeneration ) 1103

C query = axonal regeneration started Mon Dec 27 20:59:14 2010
C query resulted in 5500 titles
A AND C query resulted in 1103 titles
10281 B-terms ready on Mon Dec 27 21:03:32 2010

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
644 B-terms left after filter executed Mon Dec 27 21:14:38 2010

B-list on Mon Dec 27 21:15:27 2010
1 gdnf
2 neurotrophin
3 nt-3
4 neurturin
5 immunophilin
6 gap-43
7 mtor
8 vegf
9 akt
10 b-50
11 toll receptor
12 jnk
13 trkb
14 ciliary neurotrophic factor
15 bdnf
16 rho kinase
17 c jun
18 growth associated protein
19 neurocan
20 leukemia inhibitory factor
21 fk506
22 p38 mapk
23 phosphacan
24 netrin-1
25 galectin-1
26 nt-4
27 p38
28 c jun n
29 p75ntr
30 wld
31 cntf
32 tenascin c
33 trka
34 motor neuron disease
35 peripherin
36 gfap
37 galanin
38 tubulin gene
39 differentially expressed gene
40 expression c jun
41 ephrin
42 wallerian degeneration
43 cgrp
44 nogo a
45 drg
46 microtubule associated protein
47 lingo-1
48 myelin gene
49 p27kip1
50 neuregulin
51 calcitonin gene related
52 laminin
53 gene related peptide
54 myelin associated glycoprotein
55 neuropilin
56 creb
57 erk
58 sod1
59 cd133
60 cord transection enhancement
61 flk-1
62 psa
63 p2x
64 phosphatidylinositol 3-kinase
65 immediate early gene
66 beta tubulin
67 calpain
68 5-ht1a
69 pten
70 activating transcription factor
71 map kinase
72 chondroitin sulfate proteoglycan
73 p75
74 jun
75 nav1
76 ncam
77 fibroblast growth factor
78 spastic paraplegia
79 tdp-43
80 ng2
81 nnos
82 ngf
83 melanocortin receptor
84 erk1
85 epha4
86 trkc
87 matrix metalloproteinase
88 gap43
89 bcl-2
90 s100a4
91 cdna library
92 fk
93 cytoskeletal protein
94 ampa
95 scip
96 proteoglycan
97 abeta
98 socs3
99 pacap
100 early gene
101 demyelination
102 erythropoietin
103 p2x7
104 cdna
105 cell adhesion molecule
106 receptor kinase
107 vimentin
108 glutamate receptor
109 helix loop helix
110 atf3
111 apolipoprotein e
112 yvad
113 tenascin r
114 trk
115 nogo
116 icam-1
117 map1b
118 tubulin
119 cyclin dependent kinase
120 kv1
121 neuropeptide
122 mri
123 p75 ntr
124 novel gene
125 gene family
126 adenoviral gene transfer
127 glia
128 apolipoprotein e gene
129 eae
130 stathmin
131 ubiquitin
132 hsp27
133 protein tyrosine phosphatase
134 ephb3
135 oligodendrocyte myelin glycoprotein
136 netrin
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138 neuropeptide y
139 reg-2
140 lacz
141 beta tubulin gene
142 chemokine
143 stump
144 cadherin
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146 growth associated gene
147 myosin heavy chain
148 fgf-2
149 adenoviral gene
150 myelin basic protein
151 pleiotrophin
152 tachykinin
153 tgf beta1
154 tyrosine phosphatase
155 scar
156 midkine
157 l1
158 p2y
159 tau protein
160 ttx
161 gracile
162 ephb
163 als
164 protein kinase b
165 cyclin d1
166 casein kinase
167 transcription factor
168 carpal tunnel syndrome
169 versican
170 peripheral myelin protein
171 igf i
172 choline acetyltransferase
173 camp response element
174 glycogen synthase
175 prosaposin
176 basic protein gene
177 ngr
178 mag
179 ret
180 olfactory
181 calmodulin
182 spastic
183 kinesin
184 src
185 bcl
186 gad
187 decorin
188 chemokine receptor
189 mmp-9
190 nf kappab
191 tag-1
192 oct-6
193 regeneration related gene
194 amyotrophic lateral sclerosis
195 stab
196 tyrosine kinase
197 p300
198 igf
199 rhoa
200 cyclin
201 transgene
202 connexin
203 enhancer
204 calcitonin
205 vasoactive intestinal polypeptide
206 ca atpase
207 tnf alpha
208 sema3a
209 n cadherin
210 synapsin
211 hydrocephalus
212 protein kinase c
213 aav
214 fgf
215 associated protein
216 disc
217 nna1
218 alpha tubulin
219 spectrin
220 ornithine decarboxylase
221 protein tyrosine kinase
222 sigma
223 cue
224 apod
225 troy
226 rho
227 mbp
228 c7
229 heat shock protein
230 hrp
231 cuff
232 egf
233 gene transfer
234 inducible gene
235 potassium channel
236 erbb
237 c ret
238 p53
239 cd8
240 na k atpase
241 gabaa
242 tnf
243 ngr gene
244 rg1
245 mesh
246 bb
247 5-ht
248 integrin
249 stretch
250 barre
251 g protein activation
252 adenylate cyclase
253 rho gtpase
254 beta actin
255 gap
256 mhc
257 cytokine
258 vasoactive intestinal peptide
259 tau
260 arginase
261 fibronectin
262 abc
263 jund
264 autophagy
265 response element
266 leg
267 nf
268 epidermal growth factor
269 pain
270 protein gene
271 kinase gene
272 igf-1
273 isoform
274 multiple sclerosis

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

Start A-Literature C-Literature B-list Filter Literature

AB literature

 

B-term

 

BC literature

 

spinal cord injury gdnf axonal regeneration
1: Transgene-mediated GDNF expression enhances synaptic connectivity and GABA transmission to improve functional outcome after spinal cord contusion. 2010
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2: Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF. 2010
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3: Production of highly pure human glycosylated GDNF in a mammalian cell line. 2009
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4: A novel cell-based therapy for contusion spinal cord injury using GDNF-delivering NIH3T3 cells with dual reporter genes monitored by molecular imaging. 2008
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5: GDNF plasma levels in spina bifida: correlation with severity of spinal damage and motor function. 2008
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6: GDNF gene delivery via the p75(NTR) receptor rescues injured motor neurons. 2006
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7: Expression of GDNF in spinal cord injury and its repression by ONO-1714. 2005
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8: New approaches for the treatment of pain: the GDNF family of neurotrophic growth factors. 2005
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9: Olfactory ensheathing cells genetically modified to secrete GDNF to promote spinal cord repair. 2004
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10: The influence of GDNF on the timecourse and extent of motoneuron loss in the cervical spinal cord after brachial plexus injury in the neonate. 2004
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11: Adenovirus-mediated delivery of GDNF ameliorates corticospinal neuronal atrophy and motor function deficits in rats with spinal cord injury. 2004
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12: Suppression of GDNF production by MPSS treatment following spinal cord injury in the rat. 2004
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13: Effects of hyperbaric oxygen on GDNF expression and apoptosis in spinal cord injury. 2004
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14: Intraputamenal infusion of GDNF in aged rhesus monkeys: distribution and dopaminergic effects. 2003
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15: The spinal GDNF level is increased after transient spinal cord ischemia in the rat. 2003
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16: Bcl-2 and GDNF delivered by HSV-mediated gene transfer after spinal root avulsion provide a synergistic effect. 2002
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17: Delayed application of IGF-I and GDNF can rescue already injured postnatal motor neurons. 2001
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18: Up-regulation of glial cell line-derived neurotrophic factor (GDNF) following traumatic spinal cord injury. 2000
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19: Neuroprotective utility and neurotrophic action of neurturin in postnatal motor neurons: comparison with GDNF and persephin. 1999
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20: A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury. 1998
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21: GDNF and its receptor component Ret in injured human nerves and dorsal root ganglia. 1998
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22: A non-invasive transport system for GDNF across the blood-brain barrier. 1997
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23: Regulation of spinal motoneuron survival by GDNF during development and following injury. 1996
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1: Collagen nerve conduits releasing the neurotrophic factors GDNF and NGF. 2010
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2: GDNF-transduced Schwann cell grafts enhance regeneration of erectile nerves. 2008
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3: Expression of GDNF and its receptors in the periodontal mechanoreceptor. 2006
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4: Striatal implantation of GDNF releasing biodegradable microspheres promotes recovery of motor function in a partial model of Parkinson's disease. 2004
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5: GDNF family ligands activate multiple events during axonal growth in mature sensory neurons. 2004
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6: Simultaneous GDNF and BDNF application leads to increased motoneuron survival and improved functional outcome in an experimental model for obstetric brachial plexus lesions. 2002
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7: Rat heart GDNF: effect of chemical sympathectomy. 2002
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8: Regeneration of entorhinal fibers in mouse slice cultures is age dependent and can be stimulated by NT-4, GDNF, and modulators of G-proteins and protein kinase C. 2001
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9: GDNF gene delivery to injured adult CNS motor neurons promotes axonal growth, expression of the trophic neuropeptide CGRP, and cellular protection. 2001
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10: Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model. 2000
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11: Preparation of recombinant human GDNF by baculovirus expression system and analysis of its biological activities. 2000
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12: Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle. 1999
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13: Alterations in the neurotrophic factors BDNF, GDNF and CNTF in the regenerating olfactory system. 1998
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14: Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease. 1997
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