我国研究发现非吸烟肺腺癌人群中关键致癌基因突变谱

http://news.sciencenet.cn/htmlnews/2010/9/238016.shtm

http://jco.ascopubs.org/content/early/2010/09/17/JCO.2010.29.6038.abstract?sid=835dd89f-9fb8-451b-90e4-07ba755d8419

 知识发现平台与检索分析用词：

 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

Start A-Literature C-Literature B-list Filter Literature

A-query: Lung Adenocarcinoma C-query: Oncogenic Mutant Kinases The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 12 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 8440 and can be accessed from the start page after you leave this session. There are 582 terms on the current B-list (358 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

job id # 8440 started Sun Sep 26 23:11:41 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
8440 Search ARROWSMITH A
A_query_raw: Lung Adenocarcinoma Sun Sep 26 23:11:59 2010

A query = Lung Adenocarcinoma started Sun Sep 26 23:12:00 2010
A query resulted in 32435 titles
8440 Search ARROWSMITH C
C_query_raw: Oncogenic Mutant Kinases Sun Sep 26 23:12:40 2010

C: Oncogenic Mutant Kinases 995

A: pubmed_query_A 32435

AC: ( Lung Adenocarcinoma ) AND ( Oncogenic Mutant Kinases ) 12

C query = Oncogenic Mutant Kinases started Sun Sep 26 23:12:41 2010
C query resulted in 995 titles
A AND C query resulted in 12 titles
3741 B-terms ready on Sun Sep 26 23:13:48 2010

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
582 B-terms left after filter executed Sun Sep 26 23:16:46 2010

这些基因相关的知识隐含在文献中，对科研很有参考价值。

B-list on Sun Sep 26 23:17:58 2010
1 jnk
2 wnt
3 nm23
4 mdm2
5 akt
6 nm23-h1
7 vegf
8 k ras
9 mtor
10 stat3
11 erk1
12 mek1
13 beta catenin
14 cyclin e
15 her-2 neu
16 jak2
17 erbb-2
18 phosphatidylinositol 3-kinase
19 braf
20 egfr tyrosine
21 pi3k
22 her2
23 cdk4
24 egfr tyrosine kinase
25 pten
26 her-2
27 map kinase
28 metastasis suppressor
29 raf-1
30 e2f1
31 metastasis suppressor gene
32 mutation egfr
33 cdk2
34 caspase-8
35 p53 tumor suppressor
36 axin
37 pd l1
38 brca1
39 erbb-2 gene
40 c kit
41 cdk6
42 mek
43 microrna
44 signal regulated kinase
45 anti egfr
46 p27
47 p38 mapk
48 smad4
49 cyclin d1
50 flt-1
51 multiple endocrine neoplasia
52 cip1
53 p16ink4a
54 lkb1
55 cyclin dependent kinase
56 erbb-2 oncogene
57 smad
58 ki ras
59 flt3
60 ret
61 p16ink4
62 e cadherin
63 waf1
64 vegfr
65 erbb2
66 skp2
67 c myc
68 caspase-9
69 exon
70 her2 neu
71 mage
72 kras2
73 c jun nh2-terminal
74 caspase
75 chk2
76 egfr signaling
77 c met
78 bcl-2
79 ink4a
80 nf kappab
81 neu overexpressing
82 receptor tyrosine kinase
83 cd44
84 ha ras
85 tumor suppressor gene
86 protooncogene
87 reck
88 sp1
89 genome wide
90 aurora a
91 pik3ca
92 rassf1
93 c jun
94 caveolin-1
95 polo kinase
96 egr-1
97 stat5
98 hepatocyte growth factor
99 cadherin
100 neu oncogene
101 glycogen synthase kinase
102 telomerase rna
103 retinoic acid receptor
104 bcr abl
105 h ras
106 kdr
107 muc1
108 neurotrophin
109 egr1
110 e1a
111 pkb
112 transcription factor
113 casein kinase
114 serine threonine kinase
115 gankyrin
116 hsp90
117 receptor kinase
118 vimentin
119 flk-1
120 her-2 neu overexpressing
121 gene promoter
122 fak
123 src
124 cd117
125 jak stat
126 galectin-3
127 egfr
128 erk
129 b raf
130 crk
131 p21cip1
132 tyrosine kinase
133 tgf beta
134 ret proto oncogene
135 p glycoprotein
136 cyclin
137 erbb
138 fkhrl1
139 prb
140 akt pkb
141 e2f
142 p16
143 mkp-1
144 proto oncogene
145 nras
146 rhoa
147 pp60c src
148 connexin43
149 p38
150 ron
151 c jun n
152 growth factor gene
153 erbb-2 neu
154 bcr
155 ezrin
156 beta gene
157 c src
158 oncogene tumor
159 oncogene a
160 tumor suppressor
161 cellular oncogene
162 necl-5
163 npm
164 p21
165 nude
166 factor receptor egfr
167 oncogenic kras
168 jnk sapk
169 tbetar
170 n ras
171 c raf
172 myc
173 caldesmon
174 foxo3a
175 jak
176 e6
177 glycogen synthase
178 integrin alpha
179 egf
180 p120
181 autophagy
182 p53
183 gene nm23
184 interleukin
185 tyrosine kinase receptor
186 smad2
187 neu
188 oncogene
189 receptor gene
190 fus1
191 abl
192 p185
193 rnai
194 allele specific
195 intron
196 sonic hedgehog
197 hox
198 protein kinase b
199 map kinase kinase
200 tenascin c
201 ets
202 raf
203 syk
204 reading frame
205 jun
206 lats2
207 lck
208 n myc
209 suppressor gene
210 anaplastic lymphoma kinase
211 env
212 tumor suppressor pten
213 nf2
214 nf kappa b
215 tumor suppression
216 helicase
217 epidermal growth factor
218 p19arf
219 shp-2
220 retrovirus mediated gene
221 related gene
222 p21ras
223 hipk2
224 gnas
225 integrin
226 progesterone receptor
227 tsc2
228 expressing ret
229 ap-1
230 hgf
231 nf
232 nore1
233 e1a gene
234 proto
235 thrombopoietin
236 chaperone
237 gab1
238 kras
239 c fos
240 lysyl oxidase
241 interferon regulatory factor
242 protein tyrosine phosphatase
243 beta globin gene
244 high mobility group
245 gene transfer
246 histone acetyltransferase
247 bone morphogenetic protein
248 gene encode
249 il-6
250 promoter
251 trail
252 ki
253 tgf beta1
254 immediate early gene
255 gene human
256 tcf
257 proline rich
258 repressor
259 wilm tumor gene
260 transgene
261 alk
262 ros
263 allelic
264 wnt-1
265 yb-1
266 bim
267 rab5
268 erbb4
269 gastrin
270 tyrosine phosphatase
271 akt1
272 rb
273 gtpase
274 eif4e
275 ubiquitin
276 decoy
277 kit
278 estrogen receptor
279 expression tumor suppressor
280 beta tubulin
281 pim-1
282 poliovirus receptor
283 ha
284 il-10
285 rna helicase
286 isoform
287 insulin growth factor
288 rho kinase
289 ras
290 csf-1
291 tpa
292 pi 3-kinase
293 p300
294 b7-h1
295 fas
296 protein kinase
297 atm
298 fibroblast growth factor
299 rho family gtpase
300 atp binding
301 nucleoside diphosphate kinase
302 genomic
303 arf
304 sh3
305 igf1r
306 cd45
307 akt3
308 h-ras
309 zinc finger protein
310 copy
311 g2
312 stat-3
313 plasminogen activator gene
314 pdgfr
315 mage a4
316 prostate cancer
317 tumor suppressor lkb1
318 rela
319 response element
320 g1
321 factor gene
322 integrin alpha v
323 rac1
324 rack1
325 cdc25a
326 cdc2
327 foxo1
328 nucleophosmin
329 neu encoded
330 pdgf b
331 thyroglobulin
332 sphingosine kinase
333 retinoblastoma
334 tetraspanin
335 p65
336 protein kinase c
337 rna polymerase
338 gsk-3beta
339 pkcdelta
340 raf1
341 tumor gene
342 pkc
343 plasminogen
344 mutant allele
345 gm3
346 shp2
347 ornithine decarboxylase
348 protein tyrosine kinase
349 oncogene induced
350 dynamin
351 senescence
352 hedgehog
353 tyrosine kinase kit
354 wilm tumor
355 tcr
356 beta1
357 neu erbb2
358 domain

 

 

 

 

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