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脑疾病遗传学研究文献中的化学与药物知识发现

已有 6012 次阅读 2010-12-20 13:57 |个人分类:知识发现|系统分类:论文交流|关键词:学者| 化学, 遗传学, 知识发现, 药物, 脑疾病

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

  A-query: gene
C-query: brain diseases
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 10000 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 8583 and can be accessed from the start page after you leave this session. There are 1447 terms on the current B-list (424 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 8583 started Mon Dec 20 01:23:06 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
8583 Search ARROWSMITH A
A_query_raw: gene Mon Dec 20 01:23:22 2010

A query = gene started Mon Dec 20 01:23:25 2010
A query resulted in 50000 titles
8583 Search ARROWSMITH C
C_query_raw: brain diseases Mon Dec 20 01:23:39 2010

C: brain diseases 839194

A: pubmed_query_A 1498474

AC: ( gene ) AND ( brain diseases ) 54677

C query = brain diseases started Mon Dec 20 01:23:39 2010
C query resulted in 50000 titles
A AND C query resulted in 10000 titles
9592 B-terms ready on Mon Dec 20 01:28:33 2010

Sem_filter:
Chemicals & Drugs
1447 B-terms left after filter executed Mon Dec 20 01:34:56 2010

B-list on Mon Dec 20 01:43:00 2010
1 irinotecan
2 atorvastatin
3 toll receptor
4 vegf
5 serotonin transporter
6 p38 mapk
7 cox-2
8 proteasome
9 calcium sensing receptor
10 gemcitabine
11 clopidogrel
12 factor v leiden
13 endothelial growth factor
14 neurotrophin
15 mptp
16 secretase
17 gamma secretase
18 fenofibrate
19 mapk
20 pioglitazone
21 temozolomide
22 aquaporin
23 amyloid beta
24 gold nanoparticle
25 peroxisome proliferator activated
26 proliferator activated receptor
27 alpha synuclein
28 huntingtin
29 dopamine transporter
30 creb
31 fragile x
32 tau protein
33 statin
34 beta catenin
35 derived neurotrophic factor
36 ppargamma
37 notch signaling
38 cannabinoid
39 dexmedetomidine
40 brain natriuretic peptide
41 abc transporter
42 synuclein
43 proteasome inhibition
44 sirolimus
45 prion protein
46 chemokine receptor
47 cerebral amyloid
48 contrast enhanced
49 amyloid angiopathy
50 paclitaxel
51 apoe
52 ppar
53 gt g
54 splice
55 catenin
56 calcineurin
57 sh sy5y
58 mtdna
59 estrogen receptor beta
60 amyloid beta induced
61 chemokine
62 carboplatin
63 phenprocoumon
64 ppar gamma
65 histone deacetylase inhibitor
66 nmda receptor
67 osteopontin
68 2a receptor
69 uncoupling protein
70 melanocortin
71 peroxisome proliferator
72 cyclooxygenase-2
73 matrix metalloproteinase
74 ubiquitin
75 alzheimer amyloid
76 estrogen receptor alpha
77 orphan receptor
78 olanzapine
79 toll receptor signaling
80 nmda
81 amp activated protein
82 inflammatory cytokine
83 receptor polymorphism
84 cox-2 inhibitor
85 cb1 receptor
86 erk
87 amyloid precursor protein
88 ubiquitin proteasome
89 lt sup gt
90 jak2 v617f
91 tacrolimus
92 memantine
93 vinorelbine
94 cyclin
95 toll
96 natriuretic peptide
97 neurotrophic factor
98 simvastatin
99 hla drb1
100 amlodipine
101 valsartan
102 dystroglycan
103 retrotransposon
104 cannabinoid cb1 receptor
105 growth factor vegf
106 nadph oxidase
107 p75 neurotrophin receptor
108 cannabinoid receptor
109 antiepileptic drug
110 estrogen receptor
111 follistatin
112 niemann pick c
113 cxcr4 antagonist
114 dna methyltransferase
115 antipsychotic
116 metformin
117 prion
118 nuclear factor
119 oxidative damage
120 superparamagnetic iron oxide
121 interleukin-6
122 mitogen activated protein
123 atm
124 valproate
125 stress activated protein
126 iron oxide nanoparticle
127 role ubiquitin proteasome
128 er stress
129 posttraumatic stress
130 prion strain
131 tnf alpha
132 kinase akt
133 5-ht 1a receptor
134 abscisic acid
135 rapamycin
136 mptp mouse model
137 cyclooxygenase-2 cox-2
138 alpha7 nicotinic acetylcholine
139 histone deacetylase
140 cd8 t
141 human prion
142 defensin
143 cytosolic phospholipase
144 nuclear receptor
145 acid transporter
146 bisphosphonate
147 etoposide
148 antiepileptic
149 activated protein
150 amyloid beta production
151 presenilin gamma secretase
152 paroxetine
153 tgf
154 ganciclovir
155 ifn
156 expression matrix metalloproteinase
157 papillary thyroid
158 methicillin
159 bh3-only protein
160 tgf beta
161 metalloproteinase
162 angiotensin system
163 botulinum toxin
164 retinoic acid receptor
165 induction heme oxygenase-1
166 transcription factor
167 glutamate transporter
168 warfarin
169 cytochrome p450
170 ribavirin
171 density lipoprotein cholesterol
172 nestin
173 nuclear receptor ppargamma
174 hdl
175 app
176 rt
177 butylphthalide
178 cyclin dependent kinase
179 angiotensin receptor
180 gabab receptor
181 cpg
182 renin angiotensin
183 tcr
184 receptor signaling
185 fusion protein
186 valproic acid
187 postmenopausal hormone
188 dopaminergic
189 gaucher
190 xenograft
191 mitochondrial uncoupling protein
192 tissue plasminogen activator
193 neurotrophic
194 cyclin dependent
195 glucocorticoid receptor
196 tnf
197 botulinum toxin a
198 transthyretin
199 induced oxidative
200 effect angiotensin receptor
201 derived induced pluripotent
202 precursor protein
203 antiretroviral
204 tgf beta1
205 retinoic acid
206 il-10
207 cyclooxygenase-2 expression
208 cytokine
209 glucocerebrosidase
210 biofilm
211 neuroprotective
212 tau
213 mineral density chinese
214 interleukin-1 receptor antagonist
215 methylphenidate treatment attention
216 model assessment insulin
217 igfbp-3
218 vitamin d
219 grape seed proanthocyanidin
220 dependent insulinotropic polypeptide
221 5-ht 2a receptor
222 il-6
223 dystrophin
224 iron oxide
225 calcineurin inhibition
226 amyloid
227 tumor xenograft
228 alzheimer disease amyloid
229 mtdna mutation
230 chemokine chemokine receptor
231 gabaergic
232 anti inflammatory cytokine
233 asymmetric dimethylarginine
234 surfactant protein
235 or gemcitabine
236 beta defensin
237 heme oxygenase-1
238 cyclooxygenase-1
239 polymeric micelle
240 melanocortin receptor
241 effect statin
242 polyphenol
243 dopamine d2
244 map kinase
245 dopamine signaling
246 interferon beta
247 apolipoprotein e
248 homocysteine
249 lipid lowering
250 isoform
251 timp-1
252 minocycline
253 somatostatin receptor
254 receptor alpha
255 annexin
256 activated protein kinase
257 chronic intestinal pseudo
258 renin angiotensin aldosterone
259 lactamase
260 mtdna deletion
261 arsenic trioxide
262 growth factor beta1
263 interleukin-1 receptor
264 antipsychotic treatment
265 nuclear factor kappab
266 antioxidant defense
267 3-n butylphthalide
268 plasminogen activator
269 pparalpha
270 protein transgenic
271 ubiquitin specific protease
272 oxide synthase expression
273 cyclin d1
274 cholesterol homeostasis
275 perforin
276 monocyte chemoattractant
277 metalloproteinase-9
278 proanthocyanidin
279 checkpoint
280 response dna
281 ubiquitin chain
282 kainic acid induced
283 clock
284 mmp-9 timp-1
285 radiation induced dna
286 ppar alpha
287 tgf beta induced
288 il-1beta
289 killer cell immunoglobulin
290 tanshinone
291 thapsigargin
292 angiotensin aldosterone system
293 adapter protein
294 lt em gt
295 hdl cholesterol
296 curcumin
297 dna binding protein
298 matrix metalloproteinase-9
299 cadherin
300 nitric oxide synthase
301 glucose dependent insulinotropic
302 ornithine transcarbamylase deficiency
303 cytokine chemokine
304 panax
305 plasminogen activator inhibitor-1
306 tumor suppressor protein
307 superantigen
308 gfap
309 gaba a receptor
310 gtpase
311 tyrosine phosphorylation
312 mrna expression
313 p selectin
314 il-1 receptor
315 mapk pathway
316 lovastatin
317 t calcium channel
318 cyclase activating polypeptide
319 dopamine receptor
320 notch
321 il-1
322 cisplatin
323 expression insulin growth
324 ampa
325 signal regulated protein
326 paraoxonase-1
327 beta lactamase
328 tgf beta receptor
329 shear stress
330 podocyte
331 drug alzheimer disease
332 amino acid transporter
333 grape seed
334 prp
335 methylphenidate
336 antioxidant
337 neuroprotective agent
338 mcp-1
339 receptor modulator
340 il-1beta tnf alpha
341 androgen
342 dna copy number
343 expression protein
344 leucine rich repeat
345 activin
346 protein coupled receptor
347 lipoprotein receptor related
348 ampa receptor
349 cd4 t
350 streptozotocin induced diabetic
351 anti angiogenic
352 troponin
353 mpl
354 antiemetic
355 neuronal nitric oxide
356 g protein signaling
357 n-3 fatty acid
358 medullary thyroid
359 troponin i
360 methylmalonic
361 mrna
362 carbamazepine
363 ifn gamma
364 adipose tissue
365 role nitric oxide
366 disulfide isomerase
367 factor alpha interleukin-6
368 activated protein c
369 proton pump
370 fgf
371 nicotinic receptor
372 protein kinase ampk
373 antimicrobial
374 igf i
375 ginsenoside
376 endothelial nitric oxide
377 tetrahydrobiopterin
378 streptozotocin
379 b7-h1
380 ion channel
381 hormone releasing hormone
382 human beta defensin
383 mb
384 antihypertensive
385 amyloid pathology
386 cystatin
387 pd study
388 acid binding protein
389 histamine h1
390 nitrosative stress
391 inhibitor treatment
392 ivermectin
393 antituberculous
394 neuronal nicotinic acetylcholine
395 magnetite
396 dopamine d2 receptor
397 tyrosine kinase
398 il-8
399 naltrexone
400 p glycoprotein
401 protein kinase a
402 tight junction protein
403 growth factor expression
404 d-aspartate receptor
405 cisplatin induced
406 igf
407 pick
408 protein related
409 dependent kinase
410 drug discovery
411 interleukin-18
412 case based update
413 ligand structure based
414 biomarker pituitary
415 exhibit enhanced migratory
416 cyclophosphamide induced oxidative
417 gt lt sup
418 sup gt lt
419 combined ligand structure
420 m 3243a gt
421 3243a gt g
422 model kainic acid
423 orthotopic xenograft mouse
424 generating maintaining

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

Start A-Literature C-Literature B-list Filter Literature

AB literature

 

B-term

 

BC literature

 

gene neurotrophin brain diseases
1: [Study on reversion of malignant phenotype of glioma by siRNA targeting p75 neurotrophin receptor]. 2010
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2: Identification of potentially neuroprotective genes upregulated by neurotrophin treatment of CA3 neurons in the injured brain. 2010
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3: Stress-induced expression of the p75 neurotrophin receptor is regulated by O-GlcNAcylation of the Sp1 transcription factor. 2010
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4: Neurotrophin 3 improves delayed reconstruction of sensory pathways after cervical dorsal root injury. 2010
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1: Neurotrophins in healthy and diseased skin. 2010
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2: Neurotrophins in lung health and disease. 2010
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3: The Role of Neurotrophins in Inflammation and Allergy. 2010
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4: Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration. 2010
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5: Tryptamine-derived alkaloids from Annonaceae exerting neurotrophin-like properties on primary dopaminergic neurons. 2010
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6: Differential regulation of neurotrophin S100B and BDNF in two rat models of depression. 2010
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7: The p75 neurotrophin receptor is localized to primary cilia in adult murine hippocampal dentate gyrus granule cells. 2010
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8: Glial cell line-derived neurotrophic factor is a key neurotrophin in the postnatal enteric nervous system. 2010
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9: Maternal Deprivation Induces Depressive-like Behaviour and Alters Neurotrophin Levels in the Rat Brain. 2010
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