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组蛋白脱乙酰基酶抑制剂与白血病研究的基因知识发现

已有 5188 次阅读 2010-12-27 15:14 |个人分类:知识发现|系统分类:论文交流|关键词:学者| 基因, 知识发现, 白血病

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

Start A-Literature C-Literature B-list Filter Literature
  A-query: histone deacetylase inhibitors
C-query: acute myeloid leukemia
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 237 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 25849 and can be accessed from the start page after you leave this session. There are 1459 terms on the current B-list (881 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 25849 started Mon Dec 27 02:21:15 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
25849 Search ARROWSMITH A
A_query_raw: histone deacetylase inhibitorsMon Dec 27 02:21:25 2010

A query = histone deacetylase inhibitors started Mon Dec 27 02:21:25 2010
A query resulted in 5623 titles
25849 Select from History ARROWSMITH C
C_query_raw: histone deacetylase inhibitors Mon Dec 27 02:21:41 2010

C: histone deacetylase inhibitors 5623

A: pubmed_query_A 5623

AC: ( histone deacetylase inhibitors ) AND ( histone deacetylase inhibitors ) 5623

A_query_raw: histone deacetylase inhibitorsMon Dec 27 02:22:03 2010

A query = histone deacetylase inhibitors started Mon Dec 27 02:22:03 2010
A query resulted in 5623 titles
25849 Search ARROWSMITH C
C_query_raw: acute myeloid leukemia Mon Dec 27 02:22:58 2010

C: acute myeloid leukemia 51568

A: pubmed_query_A 5623

AC: ( histone deacetylase inhibitors ) AND ( acute myeloid leukemia ) 237

C query = acute myeloid leukemia started Mon Dec 27 02:22:59 2010
C query resulted in 50000 titles
A AND C query resulted in 237 titles
12946 B-terms ready on Mon Dec 27 02:28:27 2010

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
1459 B-terms left after filter executed Mon Dec 27 02:53:49 2010

B-list on Mon Dec 27 02:56:59 2010
1 stat5
2 p27kip1
3 aml1
4 wnt
5 c ebp
6 jak2
7 creb binding protein
8 ccaat enhancer binding
9 mdm2
10 etv6
11 akt
12 vegf
13 caspase-8
14 stat1
15 nkg2d
16 homeobox gene
17 homeobox
18 zinc finger protein
19 mtor
20 ink4b
21 p15 ink4b
22 promoter hypermethylation
23 stat3
24 e2f
25 cancer testis antigen
26 runx1
27 beta catenin
28 p16 gene
29 gata-1
30 e2f1
31 egr-1
32 caspase-3
33 p53 gene
34 abcg2
35 p300 cbp
36 evi-1
37 daxx
38 caspase
39 runx2
40 smrt
41 cyclin dependent kinase
42 n cor
43 apo2l
44 pi3k
45 ets
46 lrp15
47 sp1
48 kruppel factor
49 kruppel
50 jnk
51 ppargamma
52 cxcr4
53 raralpha
54 hox
55 pten
56 fhit
57 notch1
58 xiap
59 cpg island
60 survivin
61 runx3
62 hdac
63 hla g
64 beta globin gene
65 bcl xl
66 c ebpalpha
67 n myc
68 retinoic acid receptor
69 cd20
70 ku70
71 mcl-1
72 nod scid
73 cd34
74 microsatellite
75 pml
76 apaf-1
77 toll receptor
78 bmi1
79 chromatin remodeling
80 gata-2
81 gamma globin gene
82 myc gene
83 phosphatidylinositol 3-kinase
84 cbp
85 p73
86 cip1
87 signal regulated kinase
88 mdr1
89 transgene expression
90 histone acetyltransferase
91 c jun
92 mdr1 gene
93 wt1
94 c myc gene
95 promoter methylation
96 cox-2
97 rxr
98 swi snf
99 promoter activity
100 mek
101 microrna
102 cd95
103 bcr abl
104 p300
105 class transactivator
106 creb
107 telomerase reverse transcriptase
108 gene wt1
109 cd133
110 gene promoter
111 retinoblastoma protein
112 map kinase
113 suv39h1
114 tumor gene wt1
115 cpg island methylation
116 globin gene
117 jak
118 immunoglobulin gene
119 promoter human
120 mtg8
121 p16ink4a
122 hdac4
123 brca1
124 oct-1
125 eto
126 aurora b
127 bax
128 p38 mapk
129 activin
130 apoptosis bcr abl
131 foxp3
132 rarbeta2
133 ikaro
134 erk1
135 ezh2
136 cyclin d1
137 myb
138 cdkn2a
139 bcr abl positive
140 evi1
141 p15 ink4b gene
142 tal1
143 e cadherin
144 waf1
145 htert gene
146 c myc promoter
147 follistatin
148 c myc
149 estrogen receptor alpha
150 wilm tumor gene
151 exon
152 ctbp
153 bcl6
154 nf kappa b
155 p27
156 jak stat
157 hmlh1
158 p21cip1
159 smad
160 genome wide
161 cd14
162 cdna
163 dnmt1
164 bcl-2
165 oncogene expression
166 pax5
167 p38
168 cd86
169 annexin
170 splicing factor
171 hox gene
172 dna methyltransferase
173 nf kappab
174 satb1
175 msin3a
176 bcr
177 receptor tyrosine kinase
178 gelsolin
179 stat5b
180 upstream promoter
181 tumor suppressor gene
182 c myb
183 p19ink4d
184 bcl
185 immediate early promoter
186 topoisomerase
187 nkg2a
188 kit ligand
189 pdgfrb
190 topoisomerase i
191 helix loop helix
192 adiponectin
193 transgene
194 tcf
195 alpha globin
196 inhibition bcr abl
197 e1a
198 il-6
199 reporter gene
200 candidate tumor suppressor
201 proto oncogene
202 novel gene
203 kip1
204 repressor
205 h2ax
206 proto oncogene expression
207 aml
208 survivin gene
209 receptor promoter
210 yy1
211 proximal promoter
212 hdac3
213 igf2
214 promoter region
215 beta globin
216 erbb
217 il-2
218 cyclin b1
219 ciita
220 gata
221 cd9
222 mlh1
223 e2f-1
224 vitamin d receptor
225 bcl x
226 hoxa10
227 pkc
228 silencing tumor suppressor
229 annexin a1
230 sirt1
231 c jun n
232 histone deacetylase
233 retinoic acid induced
234 abl
235 mmp-2
236 chemokine
237 c fos
238 transcription factor
239 receptor beta2 gene
240 cd45
241 cyclin d3
242 histone h4
243 death associated protein
244 jak1
245 zap-70
246 expression p16 gene
247 hsp90
248 chk2
249 bcl11b
250 mek1
251 promoter transcription factor
252 promoter polymorphism
253 cpg
254 il-8
255 bim
256 protein kinase b
257 p18ink4c
258 src
259 hsp70 gene
260 promyelocytic leukemia
261 island promoter
262 lmo2
263 mrp2
264 smad3
265 ews
266 autophagy
267 erk
268 p57kip2
269 thiopurine s methyltransferase
270 gadd45
271 glucocorticoid receptor
272 mkp-1
273 p15 cpg island
274 igh
275 tyrosine kinase
276 ki-67
277 p15
278 p glycoprotein
279 cyclin
280 synergistic cytotoxicity
281 xist
282 enhancer
283 bcl11a
284 cpg island promoter
285 expression tumor suppressor
286 inhibitor bcr abl
287 lamin
288 tissue inhibitor metalloproteinase
289 sin3a
290 intronic
291 cml
292 jnk1
293 flt-1
294 cd8
295 id4
296 interleukin
297 mbd2
298 gene silencing
299 p16
300 rar
301 bcr abl expressing
302 hdac1
303 protein kinase c
304 mad1
305 early promoter
306 suicide gene
307 pu
308 promoter dna
309 growth factor gene
310 alpha gene
311 slp-76
312 smad4
313 globin gene cluster
314 methylation promoter
315 caspase-9
316 resistance gene mdr1
317 kai1
318 srebp
319 gene mdr1
320 inducible gene
321 virus genome
322 cdna library
323 tsa
324 jun
325 il-1beta
326 dnmt3a
327 c ebp beta
328 hdac5
329 protooncogene
330 notch-1
331 abcb1
332 silenced gene
333 cell cycle progression
334 erg
335 chemokine receptor
336 env
337 ubiquitin
338 stat
339 mgmt
340 globin enhancer
341 specific promoter
342 immediate early gene
343 heparanase
344 putative tumor suppressor
345 pp2a
346 cytokine production
347 hsp70
348 pirh2
349 mrp1
350 chop
351 protein phosphatase 2a
352 ets domain
353 retinoblastoma gene
354 laz3
355 alpha promoter
356 synergistic induction apoptosis
357 alu
358 tumor suppressor
359 cd40
360 fli1
361 ny eso-1
362 p21
363 cyclin e
364 cadherin
365 hic1
366 beta2 gene
367 reverse transcriptase promoter
368 xist gene
369 tnf alpha
370 id1
371 presenilin
372 il-5
373 nfat
374 apoptotic gene
375 oct-2
376 cd19
377 bromodomain
378 cdx2
379 myc
380 bmi-1
381 gfi-1
382 kinase inhibitor gene
383 h ras
384 th1
385 menin
386 tumor suppressor p53
387 tcr zeta
388 alternative promoter
389 dna binding
390 cdna library human
391 statin
392 il-18
393 gene family
394 p67phox
395 vimentin gene
396 lef-1
397 hoxa9
398 cyp3a4
399 regulation tumor suppressor
400 sumo
401 cd3
402 p53
403 sapk
404 cenp
405 matrix metalloproteinase
406 caat enhancer binding
407 early gene
408 tel
409 microsatellite unstable
410 gdnf
411 expression ret
412 factor gene
413 gene microarray
414 receptor gene expression
415 cbfa1
416 gp130
417 tal1 scl
418 ki ras
419 pim-1
420 ifn gamma
421 b myb
422 expression gene
423 notch
424 ifn
425 smad7
426 scid
427 elk-1
428 f9
429 p65
430 reporter gene expression
431 gstp1
432 leucine zipper protein
433 cll
434 p53r2
435 untranslated region
436 ercc1
437 oncogenic kit
438 oncogene
439 her2
440 nhl
441 interferon alpha
442 receptor gene
443 cbl
444 hl
445 ret
446 histone h1
447 h4
448 c cbl
449 snf
450 trail
451 c jun nh
452 gadd153
453 promoter a
454 glycogen synthase
455 interferon gamma
456 il-4
457 c jun nh2-terminal
458 dickkopf-1
459 ap-1
460 cbp p300
461 neurotrophin
462 hypermethylation cpg island
463 aberrant promoter methylation
464 akt pkb
465 mdr1 promoter
466 rnai
467 interleukin receptor
468 cdc2
469 allele specific
470 erbb2
471 e box
472 status promoter
473 synergistic antileukemic
474 igfbp-3
475 g2
476 cd10
477 heat shock factor
478 4-1bb
479 p tefb
480 hla
481 her-2 neu
482 factor-1alpha gene
483 promoter region human
484 gene associated
485 h19
486 suppressor gene
487 phenylalanine hydroxylase gene
488 actin gene
489 regulatory region
490 estrogen receptor
491 tgf beta
492 anti apoptotic gene
493 cre
494 s adenosylhomocysteine hydrolase
495 nf1
496 ugt1a1
497 nuclear protein
498 scl
499 heat shock protein
500 specific promoter human
501 c jun expression
502 wilm tumor
503 dnase i
504 ep300
505 betaglycan
506 exon skipping
507 tnf
508 myb oncogene
509 g1
510 reverse transcriptase gene
511 mitf
512 fas
513 characterization promoter
514 tandem repeat
515 foxo
516 usf1
517 c flip
518 promoter associated
519 id2
520 arf
521 homeodomain protein
522 catalytic domain
523 chk1
524 promoter regulate
525 helicase
526 related gene
527 atrx
528 brd7
529 cytokine
530 mage
531 atm
532 fetal globin gene
533 dicer
534 mmp-9
535 bcr abl mediated
536 virus mediated gene
537 globin
538 integrin
539 il-3
540 simplex virus genome
541 her-2
542 calreticulin
543 nod scid mouse
544 caspase-2
545 glutathione s transferase
546 lamin a
547 g9a
548 gene encoding
549 proto
550 per1
551 h2a
552 epo
553 tnfalpha
554 retinoblastoma
555 arnt
556 tcr
557 gene chromosomal
558 checkpoint gene
559 topor
560 promoter enhancer
561 rela
562 beta gene
563 chaperone
564 protamine gene
565 nf
566 oncogene a
567 dna binding protein
568 tr2
569 serum response factor
570 cd81
571 chain gene
572 promoter dna methylation
573 cd95l
574 cd24
575 interferon stimulated gene
576 egr1
577 thymidylate synthase
578 p55
579 tumor necrosis factor
580 cd154
581 embryonic globin gene
582 isoform
583 rrna
584 timp-1
585 connexin
586 nucleophosmin
587 hp1
588 response element
589 methyltransferase
590 rna binding protein
591 prion protein gene
592 igf-1r
593 fgf
594 camp response element
595 rad51
596 pig3
597 protein kinase
598 fasl
599 nk
600 hipk2
601 mds
602 hmg coa
603 cxcl10
604 lacz
605 mafk
606 protein phosphatase
607 cd4
608 endothelin
609 aurora a
610 early growth response
611 gm csf
612 lrp15 gene
613 dnase
614 p19
615 lamin a c
616 leptin
617 pbx
618 promoter
619 tgf beta1
620 mda-7
621 ctcl
622 gene human
623 acetyltransferase
624 jund
625 retrotransposon
626 core promoter
627 bex1
628 gene genomic
629 sfrp1
630 resistance gene
631 hdm2
632 microarray profiling gene
633 human genome
634 protein tyrosine phosphatase
635 muc1
636 ig
637 frizzled related protein
638 il-12
639 gene p53
640 promoter element
641 toll
642 gene chromosome
643 site promoter
644 mrp3
645 cyp1a1
646 rb
647 cd25
648 p130
649 early promoter enhancer
650 pparalpha
651 id3
652 lim
653 pha
654 fkhr
655 ink4a
656 tf
657 tbp
658 shp-1
659 vimentin
660 androgen receptor
661 gene histone
662 meis
663 clock gene
664 kit
665 c abl
666 ifn beta
667 ribosomal rna gene
668 peroxiredoxin
669 nrf2
670 proliferating cell nuclear
671 structure gene
672 casein kinase
673 promoter binding
674 importin
675 killer
676 dr4
677 pi 3-kinase
678 rna binding
679 histocompatibility complex class
680 myc target gene
681 microtubule associated protein
682 hprt
683 gene involved
684 heparanase gene
685 erythroid enhancer
686 erba
687 helicase gene
688 thioredoxin
689 ras gap
690 mcaf
691 acetyltransferase gene
692 gene cell
693 phospholipase
694 codon
695 hes1
696 kit signaling
697 genomic
698 cd1d
699 gene leukemia cell
700 iib
701 dna methyltransferase gene
702 ing1
703 copy
704 b promoter
705 myosin heavy chain
706 thioredoxin interacting protein
707 blast
708 prostate cancer
709 rho family gtpase
710 genomic imprinting
711 rt
712 tsc2
713 c ski
714 gene transfer
715 cdk1
716 reporter gene assay
717 transducin
718 calmodulin
719 ha ras
720 synergistic antitumor
721 kip
722 synergistic cytotoxic
723 h1 gene
724 rna polymerase
725 gadd45beta
726 pcr
727 ncor
728 d3
729 scf
730 tyrosine phosphatase
731 bcr abl expression
732 par-4
733 btb
734 allelic expression
735 dna cytosine-5 methyltransferase
736 rb gene
737 prion protein
738 cbl b
739 promoter proximal
740 homeobox gene expression
741 il-2 gene
742 pax6
743 clone
744 fos
745 cyclin c gene
746 hic gene
747 bcl-2 family inhibitor
748 epigenetically silenced gene
749 igf
750 histone
751 cml cell
752 hif-1alpha
753 subunit gene
754 ferritin
755 metallothionein
756 5'-untranslated region
757 fgf receptor
758 gene human cancer
759 bach1
760 rna polymerase i
761 tubulin
762 promoter activation
763 rap1
764 1f gene
765 pkc delta
766 ampk
767 lc
768 growth differentiation factor
769 mhc class gene
770 promoter sequence
771 pax3
772 gene promoter activity
773 glut1
774 tk
775 retinoblastoma gene product
776 hmgb1
777 upstream regulatory region
778 pp1
779 testis specific
780 bcl xl gene
781 predictor gene
782 transfected gene
783 block proliferation
784 gene tumor
785 polymerase
786 pkb
787 dhfr gene
788 tgfbeta
789 apo2
790 pdgf b
791 c ha ras
792 ige
793 candidate gene
794 gene a
795 cdr
796 tip60
797 suppressor gene inactivated
798 gene cluster
799 gene teratocarcinoma
800 gene cell cycle
801 b16
802 cell p53 gene
803 aromatase
804 dr5
805 tissue specific promoter
806 rac2
807 bm2
808 hydroxylase gene
809 role proto oncogene
810 icf
811 ccr5
812 h3
813 taf
814 viral gene expression
815 nad
816 promoter specific
817 pkcdelta
818 associated protein
819 cryptic
820 class i
821 egfr
822 suppressor gene chromosome
823 pu gene
824 somatostatin receptor
825 kinase protein
826 human bcr abl
827 hmg coa reductase
828 fibroblast growth factor
829 mhc
830 reduced expression
831 viral gene
832 expression ccaat enhancer
833 lipoxygenase
834 srf
835 ctp
836 p21waf
837 gene dna
838 jc
839 inducible
840 pkcepsilon
841 dynamin
842 superoxide dismutase gene
843 apolipoprotein e
844 gene locus
845 expression promoter
846 sis
847 promoter mouse
848 gtpase
849 gene leukemia
850 gene chromatin
851 ribonucleotide reductase
852 lysozyme
853 domain
854 ap1
855 allele specific expression
856 transgene accompanied
857 methylation p15 cpg
858 epigenetic gene
859 t bet
860 lps
861 hemoglobin
862 cd7
863 ros
864 promoter differentiation
865 adaptor
866 b29
867 fgf2
868 nima
869 g alpha q
870 dj-1
871 allele
872 runt
873 adp ribosyltransferase
874 human endogenous retrovirus
875 viral promoter
876 locus
877 m6
878 phenylalanine hydroxylase
879 binding promoter
880 cyclin d2
881 gene repression

 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

Start A-Literature C-Literature B-list Filter Literature

AB literature

 

B-term

 

BC literature

 

histone deacetylase inhibitors p27kip1 acute myeloid leukemia
1: Inhibition of p27Kip1 gene transcription by mitogens. 2009
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2: Histone deacetylase inhibition-mediated post-translational elevation of p27KIP1 protein levels is required for G1 arrest in fibroblasts. 2005
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1: The role of VEGF and a functional link between VEGF and p27Kip1 in acute myeloid leukemia. 2009
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2: KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells. 2008
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3: Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4. 2006
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4: Gene therapy for BCR-ABL+ human CML with dual phosphorylation resistant p27Kip1 and stable RNA interference using an EBV vector. 2006
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5: Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders. 2005
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6: The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression. 2005
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7: CD44: a new means to inhibit acute myeloid leukemia cell proliferation via p27Kip1. 2004
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8: Myeloid Leukemia Factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation. 2004
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9: Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia. 2004
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10: Prognostic significance of the cell cycle inhibitor p27Kip1 in acute myeloid leukemia. 2000
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11: Overexpression of p21Cip1 or p27Kip1 in the promyelocytic leukemia cell line HL60 accelerates its lineage-specific differentiation. 1999
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