脐带血干细胞常用于移植目的，可治疗包括白血病、骨髓瘤和淋巴瘤等血液相关疾病。在最新一期 《科学》 杂志上，加拿大蒙特利尔大学免疫学和癌症研究所（IRIC）研究人员宣布发现了一种新分子，可使单位脐带血中的干细胞数量增殖数倍。http://paper.sciencenet.cn/htmlpaper/2014101014373443634598.shtm?id=34598
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http://www.sciencemag.org/articleusage?gca=sci;345/6203/1509
Science 19 September 2014: 2014年9月19日发表 Vol. 345 no. 6203 pp. 1509-1512 10.1126/science.1256337
Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal
Iman Fares 1
Jalila Chagraoui 1
Yves Gareau 2
Stéphane Gingras 2
Réjean Ruel 2
Nadine Mayotte 1
Elizabeth Csaszar 3
David J. H. F. Knapp 4
Paul Miller 4
Mor Ngom 4
Suzan Imren 4
Denis-Claude Roy 5 , 6
Kori L. Watts 7
Hans-Peter Kiem 7 , 8
Robert Herrington 9
Norman N. Iscove 9 , 10
R. Keith Humphries 4
Connie J. Eaves 4
Sandra Cohen 5 , 6
Anne Marinier 2
Peter W. Zandstra 3
Guy Sauvageau 1 , 5 , 6 , *
+ Author Affiliations
1 Molecular Genetics of Stem Cells Laboratory, Institute of Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada.
2 Medicinal Chemistry, IRIC, University of Montreal, Montreal, QC, Canada.
3 Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
4 Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada.
5 Division of Hematology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada.
6 Department of Medicine, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada.
7 Clinical Research Division, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA.
8 Department of Medicine and Pathology, University of Washington, Seattle, WA, USA.
9 Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.
10 Department of Immunology, University of Toronto, Toronto, ON, Canada.
↵ * Corresponding author. E-mail: guy.sauvageau@umontreal.ca
The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a family of chemically related small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. The potent activity of these newly identified compounds, UM171 being the prototype, is independent of suppression of the aryl hydrocarbon receptor, which targets cells with more-limited regenerative potential. The properties of UM171 make it a potential candidate for hematopoietic stem cell transplantation and gene therapy.
Received for publication 21 May 2014.
Accepted for publication 26 August 2014.
http://www.sciencemag.org/content/345/6203/1509
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