Succinyl phosphonate (trisodium salt)

国际站：Succinyl phosphonate (trisodium salt)

中文名：琥珀酰膦酸盐

CAS：864167-45-3

品牌：MedChemExpress (MCE)

存储条件：4°C, sealed storage, away from moisture

生物活性：Succinyl phosphonate trisodium salt 是一种 α-酮戊二酸脱氢酶 (KGDHC) 抑制剂，有效抑制 (KGDHC) 在肌肉、细菌、脑和培养的人成纤维细胞中^{[1 ][4]}。 Succinyl phosphonate trisodium salt 是一种 2-oxoglutarate dehydrogenase (OGDH) 抑制剂，以细胞特异性代谢依赖性方式损害癌细胞的活力^[2]。琥珀酰膦酸三钠原位抑制谷氨酸刺激的海马神经元中谷氨酸诱导的ROS产生^[3]。 IC50 & 目标：α-酮戊二酸脱氢酶； 2-酮戊二酸脱氢酶^[1][4]； ROS 生产^[3]

参考文献：[1]. Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70.[2]. Bunik VI, et al. Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Oncotarget. 2016 May 3;7(18):26400-21.[3]. Zündorf G, et al. alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ. Neuroscience. 2009 Jan 23;158(2):610-6.[4]. Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61.