|||
基因组学技术突破可以使用较少的细胞用来绘制基因组中的表观遗传标记
Breakthrough genomics technique can be used to map...Science
A Ludwig Cancer Research study published online September 14th in Nature reports a novel technique to map specific chemical (or "epigenetic") modifications made to the protein packaging of DNA using a small population of cells. Such epigenetic marks play a central role in the regulation of the genome's expression. Led jointly by Ludwig San Diego's Bing Ren and Arne Klungland of the University of Oslo, the authors describe their application of this method to unravel a key mystery of the earliest stage of development. The new technique, named μChIP-seq, is also likely to be of notable relevance to cancer research. Very soon after fertilization, the control of embryonic development shifts from pre-existing
Medicalxpress.Com
人类垃圾基因序列可以促进翻译
Science
Human 'junk' gene sequences can promote translation
One of the biggest surprises of the past decade of genomic studies was the discovery that, contrary to previous belief, the majority of the genome is not used to produce proteins. Initially, many scientists thought that these long non-coding RNAs were non-functional "noise," but in recent studies, a growing fraction of these lncRNAs have been found to have regulatory functions. In 2012, a group from the RIKEN Center for Life Science Technologies, in collaboration with SISSA, an Italian University, discovered a new class of mouse lncRNAs, which are called "antisense" because their can pair with typical protein-coding mRNAs and enhance their translation. The team was surprised to find that pairing
Medicalxpress.Com
Archiver|手机版|科学网 ( 京ICP备07017567号-12 )
GMT+8, 2024-5-20 00:06
Powered by ScienceNet.cn
Copyright © 2007- 中国科学报社