Doxycycline | 多西环素

中文名：多西环素

国际站：Doxycycline | 多西环素

CAS：564-25-0

品牌：MedChemExpress (MCE)

存储条件：4°C, sealed storage, away from moisture

生物活性：强力霉素是一种抗生素，是一种具有口服活性的广谱金属蛋白酶 (MMP) 抑制剂^[1]。多西环素具有抗菌活性和抗癌细胞增殖活性^{[1][2][3][4][5]}。

体外：Doxycycline (0.01-10 µg/mL, 4 d) 仅在高浓度下影响胶质瘤细胞的生长^[2]。Doxycycline (0.01-10 µg/mL, 24 h) 降低 MT -SVG 细胞中浓度为 1 µg/mL 或更高的 CO1 蛋白含量^[2]。多西环素（100 ng/mL，1 µg/mL；24 小时）减少人增殖细胞系^[4].Doxycycline (0-250 μM, 72 h)抑制乳腺癌细胞的细胞活力^[5].

体内：多西环素（口服强饲法；200 或 800 mg/kg；每天一次；3 个月）以剂量依赖性方式降低未治疗 HT 小鼠的 MMP-9 活性^[3]。

参考文献：

[1]. Eusebio Manchado, et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. 2016 Jun 30;534(7609):647-51.

[2]. Anna-Luisa Luger, et al. Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems. Int J Mol Sci. 2018 May 17;19(5):1504.

[3]. Wilfried Briest, et al. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun;337(3):621-7.

[4]. Ethan Ahler, et al. Doxycycline alters metabolism and proliferation of human cell lines. PLoS One. 2013 May 31;8(5):e64561.

[5]. Le Zhang, et al. Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer. Cell Cycle. 2017 Apr 18;16(8):737-745.

[6]. Niv Y. Doxycycline in Eradication Therapy of Helicobacter pylori--a Systematic Review and Meta-Analysis. Digestion. 2016;93(2):167-73.